Antioxidant and toxicological activities of Pyrossia lanceolata (L.) Farw. extracts
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Published:2023-05-15
Issue:2
Volume:23
Page:174-178
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ISSN:1477-2701
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Container-title:Pharmacy Education
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language:
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Short-container-title:Pharm Educ
Author:
Indriani Ika Ria,
Teruna Hilwan YudaORCID,
Hendra RudiORCID
Abstract
Background: Pyrrosia lanceolata (L.) farw. is one of the Polypodiaceae species that is commonly used as a traditional medicinal plant.
Objective: The purpose of this study was to determine the antioxidant and toxic levels in the extracts of the species.
Method: The aerial portion of the specie was extracted with methanol, followed by a liquid-liquid extraction with n-hexane, dichloromethane, and ethyl acetate. DPPH radicals and the brine shrimp lethality test, , were used to assess its antioxidant activity and toxicity.
Result: The n-hexane extract exhibited no activity with IC50 values exceeding 500 μg/mL, whereas the ethyl acetate extract exhibited a high level of antioxidant activity with an IC50 value of 12.08±0.27 μg/mL. Moreover, when tested against Artemia salina leach, the toxicological level of the extracts was greater than 1000 μg/mL.
Conclusion: These findings lay the groundwork for further investigation into the process of isolating and evaluating the biological activity of secondary metabolites that were discovered in the extract.
Publisher
International Pharmaceutical Federation (FIP)
Subject
Pharmaceutical Science,Pharmacy,Education,Industrial and Manufacturing Engineering,Materials Science (miscellaneous),Business and International Management