Association of Falciparum Malaria and ABO Blood Group in Awka, Anambra State, Nigeria

Abstract

A cross-sectional randomized study was carried out to evaluate the association of falciparum malaria and ABO Blood group in Awka, Anambra State, Nigeria from the months of June to August 2018. Blood samples were collected from all study participants. Thick films were made from each blood sample, stained with 10% Giemsa using standard parasitological techniques. Agglutination technique using monoclonal Anti-sera A, B, and D were used to determine the ABO blood groups. Data generated were statistically analyzed using ANOVA test and the significance level was set at P<0.05. An overall malaria prevalence of 62% was observed among study participants. Blood groups O positive and A positive had higher malaria prevalence of 48.38% and 19.35% respectively of the total population size of patients infected, while blood groups B negative and AB negative had a lower prevalence of 0% respectively. There was no statistical significance (P> 0.05). The findings of this study showed that individuals with blood group O were susceptible to contracting uncomplicated malaria but had a higher resistance to developing severe malaria compared to non-O blood groups (A and B). To this end, therefore, malaria interventions and control strategies should be directed equally among individuals irrespective of their blood groups.