Hepatotoxicity case due to interferon beta-1a use-Reference-Cited by-同舟云学术

Hepatotoxicity case due to interferon beta-1a use

Published:2023-12-22 Issue:3 Volume:22 Page:164-167
ISSN:1303-6629
Container-title:Akademik Gastroenteroloji Dergisi
language:
Short-container-title:

Author:

YOLAÇAN Ramazan¹^ORCID,KAYA Bekir²^ORCID,KARABULUT Ümit¹^ORCID,ÜZEL Ali¹^ORCID,UÇMAK Feyzullah¹^ORCID,KAYA Muhsin¹^ORCID

Affiliation:

1. Department of Gastroenterology, Dicle University School of Medicine, Diyarbakır, Turkey

2. Department of Internal Medicine, Dicle University School of Medicine, Diyarbakır, Turkey

Abstract

Interferon β-1a is an immunomodulatory drug widely used in the treatment of multiple sclerosis. Liver dysfunction is a common side effect of this drug and usually develops within the first 6 months of starting interferon therapy. Here, we present our case who developed hepatotoxicity secondary to interferon β-1a treatment.

Publisher

Turkish Journal of Academic Gastroenterology

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference16 articles.

1. 1. Hauser SL, Bar-Or A, Comi G, et al; OPERA I and OPERA II Clinical Investigators. Ocrelizumab versus interferon beta-1a in relapsing multiple sclerosis. N Engl J Med 2017;376:221-34.

2. 2. No authors listed. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB multiple sclerosis study group. Neurology 1993;43:655-61.

3. 3. Francis GS, Grumser Y, Alteri E, et al. Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf 2003;26:815-27.

4. 4. M. Pulicken, A. Koteish, K. DeBusk, P.A. Calabresi. Unmasking of autoimmune hepatitis in a patient with MS following interferon beta therapy. Neurology 2006;66:1954-5.

5. 5. Fontana RJ, Hayashi P, Bonkovsky HL, et al. Presentation and outcomes with clinically apparent interferon beta hepatotoxicity. Dig Dis Sci 2013;58:1766-75.