ADRENAL INSUFFICIENCY AND AUTOIMMUNE PROCESSES IN THE COURSE OF COVID-19

Abstract

SARS-CoV-2 is the cause of coronavirus disease (COVID-19). Since the beginning of the pandemic, negative effects of SARS-CoV-2 have been noted not only on the respiratory system, but also on the cardiovascular, digestive or endocrine systems. One of the organs affected by SARSCoV- 2 is the adrenal glands. Through molecular mimicry, SARS-CoV-2 contributes to inducing autoimmune processes. The virus has been shown to disrupt the hypothalamic-pituitary-adrenal axis. In addition, it can contribute to adrenal infarction and hemorrhage. The above-mentioned mechanisms may either lead to adrenal insufficiency or contribute to the exacerbation of already existing disease. However, further studies and observations of a larger number of patients are needed to determine the exact role that SARS-CoV-2 plays in inducing autoimmune adrenal insufficiency.