Blood Glucose and Insulin Values on Daily Profile, M Value and Meal Tolerance in Patients with Type 2 Diabetes Mellitus (T2DM)

Abstract

Background: Authors and collaborators have continued medical practice in the Heisei Medical Welfare (HMW) group for long years for mainly two areas, extensive care for the elderly and diabetes research. From both of them, the current research was held on the daily profile of glucose and insulin for patients with type 2 diabetes mellitus (T2DM). Subjects and Methods: Cases were 6 T2DM patients in admission, with ages 67.5 ± 12.7 years, diabetes duration 9.5 years. Methods included a daily profile of glucose and insulin for seven times per day, Morbus (M) value, Meal Tolerance Test (MTT) using breakfast with 70g carbohydrate, insulinogenic index (IGI)-2 hours, various correlations among HbA1c, M value, Area Under the Curve (AUC) of glucose and insulin. Results: Cases showed average values of HbA1c 8.4 ± 0.7%, glucose 197 mg/dL, M value 111. Glucose and IRI levels increased during 0700-0900h with 154-258 mg/dL and 13.8-54.3 μU/ml. There was a significant correlation between Glucose-⊿AUC and M value (p<0.05). Discussion: Daily profile of glucose and insulin showed a similar manner, suggesting post-prandial glucose influence due to carbohydrate intake. When studied cases increase, significant correlations among M value, HbA1c and glucose-AUC seem to be found. This report hopefully becomes a reference for future diabetic research.