Role of TGF-beta1 and TNF-alpha1 produced by neoplastic cells in the pathogenesis of fibrosis in patients with hematologic neoplasms

Author:

Takizawa Haruko1,Araki Yoshihiko2,Fujishiro Maki3,Tomita Shigeki4,Kishikawa Satsuki4,Hashizume Akane4,Mitsumori Toru1,Nitta Hideaki1,Iizuka-Honma Hiroko1,Sawada Tomohiro5,Okubo Mitsuo6,Sekiguchi Yasunobu7,Ando Miki8,Noguchi Masaaki1

Affiliation:

1. Department of Hematology, Juntendo University Urayasu Hospital, Chiba, Japan,

2. Department of Pathology and Microbiology, Division of Microbiology, Nippon University School of Medicine, Tokyo, Japan,

3. Institute for Environmental and Gender-Specific Medicine, Juntendo University Urayasu Hospital, Chiba, Japan,

4. Department of Diagnostic Pathology, Juntendo University Urayasu Hospital, Chiba, Japan,

5. Department of Clinical Laboratory, Juntendo University Urayasu Hospital, Chiba, Japan,

6. Laboratory of Blood Transfusion, Juntendo University Urayasu Hospital, Chiba, Japan,

7. Hematology Clinic, Saitama Cancer Center, Saitama, Japan,

8. Division of Hematology, Juntendo University Juntendo Hospital, Tokyo, Japan

Publisher

Japanese Society for Lymphoreticular Tissue Research

Subject

General Medicine

Reference15 articles.

1. 1 Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012; 18: 1028-1040.

2. 2 Tefferi A, Gangat N, Pardanani A, Crispino JD. Myelofibrosis: Genetic Characteristics and the Emerging Therapeutic Landscape. Cancer Res. 2022; 82: 749-763.

3. 3 Sekiguchi Y, Shirane S, Takizawa H et al. T-cell lymphoma complicated by myelofibrosis: report of three cases and review of literature. Int J Clin Exp Pathol. 2016; 9: 7836-7853.

4. 4 Sekiguchi Y, Shirane S, Shimada A et al. Peripheral T cell lymphoma, not otherwise specified with myelofibrosis: report of a case with review of the literature. Int J Clin Exp Pathol. 2015; 8: 4186-4203.

5. 5 Shirane S, Araki M, Morishita S et al. Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential thrombocythemia. Int J Hematol. 2015; 101: 148-153.

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