EFFECT OF SELENIUM AND N-(P-AMYLCINNAMOYL) ANTHRANILIC ACID ON DOXORUBICIN-INDUCED KIDNEY INJURY IN RATS
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Published:2022-12-16
Issue:
Volume:
Page:
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ISSN:2147-7892
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Container-title:İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi
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language:tr
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Short-container-title:JHVS
Author:
YILDIZHAN Kenan1ORCID, HUYUT Zübeyir2, ALTINDAĞ Fikret2, UÇAR Bünyamin2ORCID
Affiliation:
1. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOFİZİK ANABİLİM DALI 2. VAN YUZUNCU YIL UNIVERSITY
Abstract
Doxorubicin (DOXR) is an important antitumor drug. However, the clinical use of DOXR has been limited due to serious undesirable side effects in many organs. This study aimed to analyse the effect of Selenium (Se) and N-(p-Amylcinnamoyl) Anthranilic Acid (ACA) on kidney tissue in DOXR, DOXR+Se, DOXR+Se+ACA. At the end of the study, the rat’s intracardiac blood and kidney tissues were removed under anaesthesia. Urea and creatinine levels were examined in serum samples taken from rats. In addition, histopathological examination and 8-OHdG expression in kidney tissue were determined by immunohistochemical analysis. After Se and ACA treatments, DOXR, glomerular atrophy, dilatation in tubular and glomerular, congestion in vessels, and vocalization in tubular epithelial cells were improved to varying degrees in the treatment groups with Se and ACA. In addition, Se and ACA treatments reduced the increasing expression of 8-OHdG caused by DOXR (p< 0.05). These findings indicated that Se and ACA might be used as important therapeutic agents to inhibit renal dysfunction and oxidative DNA damage after DOXR-induced kidney injury.
Publisher
Inonu University
Subject
Management, Monitoring, Policy and Law,Geography, Planning and Development
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