The effect of ascorbic acid on leukocyte reduction in burns injury patient: A short communication

Abstract

Link of Video Abstract: https://youtu.be/-_-efYtOGxk   Introduction: Challenges in managing burn injury include a high risk of sepsis and mortality. The study aimed to determine the effect of ascorbic acid on leukocyte reduction in burns injury patients. Methods: The design of this study was a case series reported using retrospectives. Data collection was carried out from January to December 2020. All participants were diagnosed with burn injuries. Participants received burn wound care with and without ascorbic acid or Vitamin C (Vit. C). Participants measured leukocyte levels on the first and fifth days. Result: The mean age of the participants was 32.08 ± 17.78 years, of which most of the participants were men (59.38%) with an average age of 35.21 ± 13.45 years, while the average age in women was 27.51 ± 22.52 years old. The mean TBSA of participants was 34.20 ± 21.21%, of which the mean TBSA for males was 39.45 ± 20.01% and for females 26.54 ± 21.32%. The mean participant leukocyte value on the first day was 21.49 ± 9.55 × 103/µL and on the fifth day, it was 11.26 ± 3.86 × 103/µL (z = -4.507; p <0.001). There was a significant difference in the leukocyte participant values on days 1 and 5 of -10.23 ± 9.77 × 103/µL (t = -2.504; p = 0.018). Conclusion: Use of Vit. C in the management of burn injury has been shown to significantly reduce the number of leukocytes on the fifth day and reduce the risk of sepsis and mortality.