CRP Levels, Thrombocyte Index and Coagulation Status with TEG Profile in ITP Patients

Abstract

Examinations related to Immune Thrombocytopenia (ITP) cases have been widely demonstrated in diagnosing and monitoring hemostasis status. The increased MPV and PDW have a high sensitivity to the diagnosis of ITP and CRP is one of the causes of ITP. Monitoring of bleeding in ITP still uses conventional examination. Thromboelastography (TEG) is a global hemostasis assessment tool that assesses real-time overall hemostasis. TEG profiles especially MA and R-time can be used for case assessment of ITP patients. This research describes the correlation between CRP levels, platelet index and coagulation status with TEG profiles (MA and R-time) in ITP patients. This research used analytical observational with cross sectional approach. A sample of 32 respondents aged >18 years with a platelet count <150,000/mm3. Then the respondents measured EDTA blood samples for platelet index (MPV and PDW) and CRP levels, in the citrate blood sample 3.2% measured coagulation status (aPTT and PT) as well as examining the TEG profile, especially R-time and MA. Correlation test uses the Pearson test for data that is normally distributed, while the Spearman test is for data that are not normally distributed. There is a correlation between CRP levels, platelet counts, MPV and MA TEG (p=0.002, p=0.000, p=0.001), there is no correlation between PDW and MA TEG (p=0.06), there is a correlation between aPTT and R-time TEG (p=0.001) and there is no correlation between PT and R-time TEG (p=0.667). Overall, there is a correlation between conventional variables and the TEG profile in ITP patients.