Hba1c levels correlated to lipoprotein-associated phospholipase A2 and monocyte HDL ratio in type 2 diabetes mellitus

Abstract

Background: In the last few decades, several hypotheses have been proposed to explain the pathogenesis of type 2 diabetes mellitus (T2DM) that links this disease with a systemic chronic inflammatory state. New predictors of lipoprotein-associated phospholipase A2 (Lp-PLA2) and monocyte HDL-c ratio (MHR) has been observed to predict atherosclerosis severity, progression of atherosclerosis and cardiovascular events. The study aims to evaluate correlation between HbA1c with Lp-PLA2 and MHR in patients with T2DM.Methods: Analytic observational research with cross sectional design. HbA1c levels were measured by high-pressure liquid chromatography, Lp-PLA2 values using the ELISA method, and MHR values based on the ratio of absolute monocytes to HDL counted manually.Results: The study was conducted on 42 DMT2 patients aged 34-74 years, mean value HbA1c, Lp-PLA2, and MHR were 8.16±2.10, 217.20±42.49, 10.55±6 11 respectively. Statistical analysis showed a positive correlation between HbA1c  and Lp-PLA2 levels (p=0.046 and r=0.310), and there was a correlation between HbA1c levels and MHR values  (p=0.038 and r=0.321).Conclusion: A weak positive correlation between glycemic control (HbA1c) and atherosclerotic markers (Lp-PLA2 and MHR) in DMT2 patients.