Type of anemia correlate with ferritin levels in patients with Chronic Kidney Disease (CKD): a cross sectional study

Abstract

Background: Anemia is the most common complication due to CKD. Normocytic normochromic is the most common type of anemia in CKD is, but there is also some microcytic hypochromic. Clinical examination such as erythrocyte indices examination and monitoring serum ferritin levels can help diagnose anemia in CKD. The purpose of this study is to determine the correlation between erythrocyte indices and ferritin levels in CKD patients in the hemodialysis unit of PKU Hospital Bantul.Methods: This research involved 50 CKD patients at PKU Hospital Bantul. Blood samples were taken to check ferritin levels and erythrocyte indices consisting of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). This study was conducted by cross-sectional study design. Data were analyzed using SPSS version 20 for Windows.Results: The average hemoglobin level was 8.46±1.31 g/dL in males and 7.92±0.90 g/dL in females. Most of the hematological profile was predominant in male patients such as in MCV (89.36±6.72 fl), MCH (29.12±2.76 pg), and MCHC (32.95±0.96 g/dL). However, the average ferritin level (352.51±544.74 ng/mL) was predominant in female patients (399.99±680.96 ng/mL). There was a significant correlation between MCH and ferritin levels (r = 0.364; p = 0.009) and MCHC with ferritin levels (r = 0.295; p = 0.038). However, there was no significant correlation between MCV and ferritin levels (r = -0.059, p = 0.683).Conclusion: There is a significant correlation between MCH and MCHC levels with ferritin levels. In addition, the patients had normal MCV, MCH, and MCHC values with normocytic normochromic anemia.