Effect of oncom extract on the level of estrogen hormone of productive white rats

Abstract

Introduction: Oncom is a processed soybean that contains isoflavone compounds. The types of isoflavones found in soybeans and their dairy products are daidzein and genistein which have an estrogenic effect on animals' reproductive performance. This study aimed to determine the effect of oncom extract on productive age white rats (Rattus norvegicus) estrogen levels.Methods: This research is an experimental study with a randomized posttest control group design. We used 21 samples divided into three groups. First group was control without being given oncom extract. The second group was given a black oncom extract dose of 0.005 g/g BB. The third group was given red oncom extract of dose 0.005 g/g body weight. Serum collection for estrogen hormone level measurement was collected on day 14 after administration of oncom extract. Data then analyzed to determine the normality and homogeneity. ANOVA test was used to compare the means between groups. P<0.05 was significant.Result: We found in the control group with the lowest estrogen level mean (16.70±0.581) than the experimental groups. The ANOVA analysis results showed that oncom extract significantly increase estrogen levels of productive age white rats (p<0.05).Conclusion: Oncom extract can increase the estrogen level in productive age white rats. However, the estrogen levels between red oncom and black oncom showed an insignificant difference.