Steroid impact on the efficacy and safety of SARS-CoV-2 vaccine: a systematic review

Author:

Pujo Prawiro Negoro ,Gatot Soegiarto ,Laksmi Wulandari

Abstract

Background: The COVID-19 vaccine has become the utmost protection against the pandemic, with billions of doses has been used across the globe. Immunosuppression has been one of the leading issues in the vaccination program, one of which should not be handled lightly is the use of the steroid. Thus, this systematic review is aimed to explore the Impact of steroid use on the efficacy and safety of the COVID-19 vaccine. Methods: The systematic review is conducted based on the PRISMA guideline by conducting a literature search and screening process through several databases (PubMed, ScienceDirect, Scopus, and EBSCOHost) based on the predetermined PICO criteria. Original articles (Controlled trial or cohort) on the use of steroids in healthy or non-immunocompromised or autoimmune patients were included. The included articles were then assessed for risk of bias using the ROBINS-I tool. Results: 6,857 articles were screened, with two articles included for the final analysis. The results show a non-significant Impact of steroid use on the vaccine efficacy based on seropositivity and antibody count. However, steroid use is related to milder adverse effects and symptoms. Conclusion: Steroid is not associated with lower response to the COVID-19 vaccine. Further research on the dose-dependent response to steroid use should be conducted.

Publisher

DiscoverSys, Inc.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3