Synthesis and Characterization and Antifungal Screening Studies of Some Novel Imidazole Derivatives

Abstract

Imidazole derivatives are five-mamboed heterocyclic having nitrogen, and oxygen atoms in their ring structure and exhibiting potent as well as wide range of pharmacological activities. Current investigations of imidazole derivatives have provided information that these derivatives may have applications in antimicrobial, antifungal, antiviral, as well as antidiabitic treatments. Fen bam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. The imidazole ring system is present in important biological building blocks such as histamine, and the related hormone histamine. Imidazole can serve as a base and as a weak acid. Many antifungal drugs such as nitroimidazole contain an imidazole ring. Thus, varied pharmacological activities of 2-amino-1-methyl-1H-imidazol-4(5H)-one derivatives have encouraged us to design and synthesize some of new class of heterocycles containing imidazolering and its derivatives. Different isomeric secondary amine containing bicyclical aromatic heterocyclic compounds were treated with 2-amino1-methyl-1H-imidazol-4(5H)-one in presence of base by using DMF as solvent and HBTU as coupling agent to get target compounds. Pure target compounds were characterized by 1H NMR, 13C NMR and LC-MS. Some of the selected imidazole derivatives were screened for their antifungal activities.