Abstract
The purpose was to explore the spatial centrality of the whole brain functional network related to migraine and to investigate the potential functional hubs associated with migraine. 32 migraine patients and 55 healthy controls were recruited and they received resting-state functional magnetic resonance imaging voluntarily. Voxel-wise Degree Centrality (DC) was measured across the whole brain, and group differences in DC were compared. False Discovery Rate and permutation test (5000 times) were used for multiple comparisons. Finally, significant differences in functional connectivity (FC) between seeds and other brain regions were further researched by the seed-based approach. The correlation analyses between the changes in the brain function and clinical features were also performed. The results showed that, compared to healthy controls, migraine patients exhibited significantly increased DC in the left anterior cingulate cortex (ACC), slightly increased DC in the right ACC and the right medial superior frontal gyrus (SFG). No significant correlation was found between DC and clinical variables. The seed-based analyses showed that migraine patients showed increased FC between the right SFG and left ACC, decreased FC between the left ACC and left superior temporal gyrus (STG). FC value of the right SFG was positively correlated with the score of migraine-specific quality-of-life questionnaire about role in function-preventive in migraine patients. According to relatively changed DC, we found that migraine patients exhibited specific abnormal intrinsic functional hubs. These findings expand our understanding of functional characteristics of migraine, and may provide new insights into understanding the dysfunction and pathophysiology of migraine patients.