Dyslipidemia is positively associated with cervical cancer in Korea: Korean national health and nutrition examination survey 2010—2020

Abstract

Several previous papers have reported that hypoxic environments induced by hypertension, Insulin like growth factor-1 (IGF-1) overexpressed by hyperinsulinemia, hyperactivity of fatty acid metabolism, stimulation of cell growth signaling factors, and formation of carcinogen by dyslipidemia contribute to tumor cell proliferation.Therefore, we hypothesized that hypertension, diabetes, and dyslipidemia are positively correlated with cervical cancer; the purpose of this study was to evaluate this correlation. We included 25,055 participants from the Korean National Health and Nutrition Examination Survey between 2010 and 2020. The participants were divided into the non-cervical cancer and cervical cancer groups. For comparisons between the two groups, continuous variables were analyzed using Student’s t-test, and categorical variables were analyzed using the chi-squared test or Fisher’s exact test. The odds ratios (OR) in the non-cervical cancer group, and 311 females were included in the cervical cancer group. In the cervical cancer group, dyslipidemia had an adjusted OR (AOR) of 2.88 compared with that of the non-cervical cancer group (AOR: 2.88, confidence interval (CI): 1.785–4.654, p < 0.001) after adjusting for confounding variables such as age, education level, waist circumference, body mass index (BMI), and number of pregnancies in the multivariate logistic regression analysis. Among the three major chronic diseases, dyslipidemia was positively correlated with cervical cancer. Therefore, Encouraging gynecologists to get proper treatment for dyslipidemia in gynecological patients with dyslipidemia is believed to help lower the potential risk of cervical cancer in the future.