Promising biocemical markers of Parkinson's disease

Abstract

Parkinson's disease (PD) is a chronic neurodegenerative disease associated with specific neurological deficits in patients, it mainly affects dopaminergic neurons in the substantia nigra causing accumulation of the neurotoxic amounts of aggregated α-synuclein protein in the neuronal cell bodies. The paper reports the authors' view of certain pathochemical and biochemical aspects of the Parkinson’s disease development in terms of interplay between the metabolic pathways of catecholamines and pigments, particularly the possible pathway of neuromelanin synthesis in the neuronal cell bodies and its importance in the life of cells. Assessment of the use of certain neurodegenerative disorder biomarkers, which are of direct pathognomonic value, in the laboratory diagnosis of the disease is provided. It is suggested to use the results in the field of deeper understanding of biochemical patterns underlying neuronal death for early diagnosis of PD in individuals of different age groups, as well as for further study of pathogenesis based on fundamental biochemistry and pathobiochemistry of intracellular processes.