Potential of non-traditional cell cultures for production of biotherapeutic proteins-Reference-Cited by-同舟云学术

Potential of non-traditional cell cultures for production of biotherapeutic proteins

Published:2024-06 Issue:2024(3) Volume: Page:
ISSN:2542-1204
Container-title:Bulletin of Russian State Medical University
language:en
Short-container-title:BRSMU

Author:

Dobronos MA¹^ORCID,Osipova ZM²,Myshkina NM³

Affiliation:

1. Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Russia

2. Pirogov Russian National Research Medical University, Moscow, Russia

3. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia

Abstract

Production of biotherapeutic drugs in mammalian cells, recombinant proteins in particular, may be handicapped by the limitations imposed on the cultures by metabolic burden. An alternative solution is to produce proteins in cells of other animals (e.g., Sf9, S2 and High Five insect cell lines, Caenorhabditis elegans and Schistosoma mansoni cell line) or orthogonal cell systems, including plant-based. In our opinion, non-traditional cell cultures may become promising tool for production of affordable and effective biotherapeutic drugs.

Publisher

Pirogov Russian National Research Medical University

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