Androgen levels in blood and follicular fluid of IVF patients with diminished ovarian reserve-Reference-Cited by-同舟云学术

Androgen levels in blood and follicular fluid of IVF patients with diminished ovarian reserve

Published:2022-08 Issue:2022(4) Volume: Page:
ISSN:2542-1204
Container-title:Bulletin of Russian State Medical University
language:en
Short-container-title:BRSMU

Author:

Gavisova AA¹^ORCID,Shevtsova MA¹,Kindysheva SV¹,Starodubtseva NL¹,Frankevich VE¹^ORCID,Nazarenko TA¹,Dolgushina NV¹

Affiliation:

1. Kulakov national medical research center for obstetrics, gynecology and perinatology, Moscow, Russia

Abstract

Androgen concentrations in follicular fluid samples collected from patients undergoing in vitro fertilization (IVF) may provide useful clinical indicators. This study aimed to analyze possible associations of the androgen levels in follicular fluid and blood plasma in patients with diminished ovarian reserve (POR) in IVF programs. Cross-sectional study with a parallel group design, conducted in 2019–2021, enrolled 300 patients with infertility, aged 18–42 years, applying for assisted reproduction involving IVF/intracytoplasmic sperm injection and embryo transfer. The androgen profiles of blood plasma and follicular fluid were determined by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Androgen concentrations in blood plasma and follicular fluid, particularly those of dehydroepiandrosterone (DHEA-S), androstenedione and total testosterone, significantly correlated. The results implicate androgen levels in blood plasma and follicular fluid as early markers of POR in patients with infertility.

Publisher

Pirogov Russian National Research Medical University

Subject

General Medicine

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