The Effects of Therapeutic Intermittent Hypoxia Implementation on Complete Blood Count Parameters: An Experimental Animal Model-Reference-Cited by-同舟云学术

The Effects of Therapeutic Intermittent Hypoxia Implementation on Complete Blood Count Parameters: An Experimental Animal Model

Published:2022-01-18 Issue: Volume: Page:
ISSN:2459-1459
Container-title:Clinical and Experimental Health Sciences
language:en
Short-container-title:

Author:

KILIÇ Talha¹,SENGOR Mustafa²,ÜSTÜNOVA Savaş³,KILIC Aysu³,DAŞKAYA Hayrettin³,ÖZER Aysel Yıldız¹

Affiliation:

1. MARMARA UNIVERSITY, FACULTY OF HEALTH SCIENCES

2. MARMARA UNIVERSITY, FACULTY OF TECHNOLOGY

3. BEZMI ALEM FOUNDATION UNIVERSITY

Abstract

Objective: Intermittent hypoxia (IH) implementation is a method performed by intermittently decreasing oxygen concentration in inhaled air at specific rate. This method varies between studies in terms of its application. This study aims to examine the changes in Complete Blood Count (CBC) parameters caused by IH implementation at therapeutic dose ranges with a single model. Methods: Ten Sprague Dawley type adult male rats were divided into two groups. In the study group, FiO2 level of inhaled air, was reduced to 10% in hypoxic cycle. 5 minutes normoxia-hypoxia cycle was used in each 30 minutes experiment period for study group. Control group remained in normoxic air for 30 minutes. 1 cc of blood was taken from mandibular vein from all rats at the end of 6th day. CBC analyzes were performed and differences between two groups were investigated. Results: Significant differences were detected in some CBC parameters between the two groups. It was determined that significant increase in MONO (p

Publisher

Marmara University

Subject

General Materials Science

Reference31 articles.

1. Guang Y, Jie Z, Feng D, Hui L. Surrogate scale for evaluating respiratory function based on complete blood count parameters. J Clin Lab Anal 2018;32(5):e22385.

2. Xing T, Pilowsky PM. Acute intermittent hypoxia in rat in vivo elicits a robust increase in tonic sympathetic nerve activity that is independent of respiratory drive. J Physiol 2010;588(Pt 16):3075-3088.

3. Navarrete-Opazo A, Mitchell GS. Therapeutic potential of intermittent hypoxia: a matter of dose. Am J Physiol Regul Integr Comp Physiol 2014;307(10):R1181-1197.

4. Baker TL, Mitchell GS. Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats. J Physiol 2000;529 Pt 1(Pt 1):215-219.

5. Ryan S, Nolan P. Episodic hypoxia induces long-term facilitation of upper airway muscle activity in spontaneously breathing anaesthetized rats. J Physiol 2009;587(Pt 13):3329-3342.