Copeptin as a diagnostic PH marker in acute pulmonary embolism-Reference-Cited by-同舟云学术

Copeptin as a diagnostic PH marker in acute pulmonary embolism

Published:2022-04-26 Issue: Volume: Page:
ISSN:2459-1459
Container-title:Clinical and Experimental Health Sciences
language:en
Short-container-title:

Author:

BAYKAN Necmi¹^ORCID,YAKAR Şule²^ORCID,ÖZKAN Seda³^ORCID,ŞEN Ahmet⁴,SALT Ömer⁵,DURUKAN Polat⁶

Affiliation:

1. Nevsehir State Hospital

2. Sağlık Bilimleri Üniversitesi, Kayseri Şehir Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği

3. Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine

4. Van Education and Research Hospital

5. Trakya Üniversitesi Tıp Fakültesi, Acil Tıp Anabilim Dalı

6. Medical Park Gaziantep Hastanesi, Acil Servis

Abstract

Objective: The present study aimed to investigate the effectiveness of copeptin levels in detecting increased pulmonary artery pressure and right ventricular dysfunction in patients with acute pulmonary embolism. Methods: A total of 116 patients who presented to the emergency department with chest pain or dyspnea and were diagnosed with acute pulmonary embolism and 30 healthy controls were included in the study. Plasma copeptin levels of patients and healthy control group were measured. Right ventricular functions and pulmonary artery pressures were evaluated in echocardiography of patients diagnosed with acute pulmonary embolism. Results: Copeptin levels were significantly higher in patients with right ventricular dysfunction than in those without right ventricular dysfunction [median 1.06(0.03–7.14) vs. 0.59(0.31–2.50), p= 0.01]. Conclusion: Copeptin can be used as a new biomarker in the diagnosis of acute pulmonary embolism and in predicting right ventricular dysfunction and increased pulmonary artery pressure in patients with acute pulmonary embolism

Publisher

Marmara University

Subject

General Materials Science

Reference20 articles.

1. [1] İpekci A. Pulmonary Embolism. Phnx Med J 2019;1(1):51-63.

2. [2] Ozturk N, Baygutalp NK, Bayramoglu A, Polat H, Gul MA, Bakan E, Aslan S, Gunes ON. The evaluation of serum copeptin levels and some commonly seen thrombophilic mutation prevalence in acute pulmonary embolism. Biochemical Genetics 2016;54(3):306-312.

3. [3] Kalkan AK, Ozturk D, Erturk M, Kalkan ME, Cakmak HA, Oner E, Uzun F, Tasbulak O, Yakisan T, Celik A. The diagnostic value of serum copeptin levels in an acute pulmonary embolism. Cardiology Journal 2016;23(1):42-50.

4. [4] Volpi S, Rabadan-Diehl C, Aguilera G. Vasopressinergic regulation of the hypothalamic pituitary adrenal axis and stress adaptation. Stress 2004;7:75–83.

5. [5] Bolignano D, Cabassi A, Fiaccadori E, Ghigo E, Pasquali R, Peracino A, Peri A, Plebani M, Santoro A, Settanni F, Zoccali C. Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology. Clin Chem Lab Med 2014;52(10):1447–1456.