Affiliation:
1. YÜZÜNCÜ YIL ÜNİVERSİTESİ
2. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, FEN FAKÜLTESİ, KİMYA BÖLÜMÜ
3. HAKKARİ ÜNİVERSİTESİ, SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU
4. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ
Abstract
Objective: Carbonyl formation between various oxidative modifications of amino acids in proteins can be an early sign of protein oxidation.
Methods: The 2,4-dinitrophenylhydrazine (DNPH) method is the most reliable method widely used to measure carbonyl levels in proteins. In this study, the effect of Rheum ribes L. (Rr) and quercetin on proteın carbonyl, trace elements (Fe, Cu, Zn) and mineral (P) levels against carbon tetrachloride (CCl4) mediated liver and kidney damage was investigated. For this purpose, 56 Wistar albino female rats weighing 200 ± 220 g were used. Groups were designed as: controls, 0.3 ml DMSO, 1 ml/kg olive oil, 1 ml/kg CCl4, 100 mg/kg Rr, 100 mg/kg quercetin, 100 mg/kg Rr+1 ml/kg CCl4 and 100 mg/kg quercetin+1 ml/kg CCl4 groups.
Results: Statistical analysis showed that in the CCl4 group was significantly higher than the control, olive oil, Rr., and quercetin groups in the PCO levels (p
Subject
General Materials Science
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