Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats-Reference-Cited by-同舟云学术

Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats

Published:2023-12-29 Issue:4 Volume:13 Page:748-752
ISSN:2459-1459
Container-title:Clinical and Experimental Health Sciences
language:
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Author:

AKÇE Ezgi¹^ORCID,DEMİRCİ DELİPINAR Sibel²^ORCID,KURU Leyla³^ORCID,YILDIRIM Hatice Selin³^ORCID

Affiliation:

1. MARMARA UNIVERSITY, INSTITUTE OF HEALTH SCIENCES, PERIODONTOLOGY (DR)

2. BIRUNI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF HISTOLOGY AND EMBRYOLOGY

3. MARMARA UNIVERSITY, FACULTY OF DENTISTRY, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF PERIODONTOLOGY

Abstract

Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid (HA) mouthwash on healing of secondary palatal wound in diabetic (D) rats. Methods: 60 Wistar albino male rats were divided into D and non-diabetic (ND) groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mg/kg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mg/kg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12% HA mouthwash and saline (S) (n=12 per group), depending on the agent to be administered to the wound area (WA). On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software. Results: The WA decreased with time in each group (p

Publisher

Marmara University

Subject

General Materials Science

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