Neuropsychological and Clinical Correlations of Optical Coherence Tomography Findings in Patients with Schizophrenia-Reference-Cited by-同舟云学术

Neuropsychological and Clinical Correlations of Optical Coherence Tomography Findings in Patients with Schizophrenia

Published:2023-12-29 Issue:4 Volume:13 Page:739-747
ISSN:2459-1459
Container-title:Clinical and Experimental Health Sciences
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Author:

SAKALLI KANİ Ayşe¹^ORCID,ŞAHİN ÇAM Cansun²^ORCID,BİBEROĞLU ÇELİK Esra¹^ORCID,DURAL Uzay³^ORCID,DURAN DÖNMEZ Melike⁴^ORCID,AKKAYA TURHAN Semra¹^ORCID,TOKER Ebru⁵^ORCID,YILDIZ Mesut¹^ORCID

Affiliation:

1. MARMARA ÜNİVERSİTESİ, TIP FAKÜLTESİ

2. Gümüşhane State Hospital

3. ISTANBUL MEDENIYET UNIVERSITY

4. UNIVERSITY OF HEALTH SCIENCES, İSTANBUL ERENKÖY APPLICATION AND RESEARCH CENTER FOR PSYCHIATRIC AND NERVE DISEASES

5. West Virginia University

Abstract

Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters. Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters. Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p

Publisher

Marmara University

Subject

General Materials Science

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