Affiliation:
1. ORDU ÜNİVERSİTESİ, TIP FAKÜLTESİ
2. Başakşehir Çam ve SAkura Hastanesi Biyokimya Bölümü
3. Bağcılar Eğitim Araştırma Hastanesi Dahiliye Bölümü
Abstract
Objective: Abnormal immune inflammatory response and cytokine storm play an important role on the aspect of increasing mortality in Covid-19. We aimed to investigate whether the Platelet Activating Factor Acetylhydrolase activity (PAF-AH) and hematological parameters have prognostic and predictive value in determining the disease severity.
Methods: A total of 84 Covid-19 patients, 52 of whom were hospitalized in the ward and 32 in the intensive care unit (ICU), and 38 control patients were included in this study.
Results: Lymphocyte and serum albumin levels were significantly lower (p < .001) and age, neutrophils, CRP, procalcitonin, LDH, INR, D-dimer levels were significantly higher (p < .001) in Covid-19 patients compared to the control group. ICU patients had significantly lower (p < .001) lymphocyte, albumin values and significantly higher (p < .001) age, leukocyte, neutrophils, CRP, INR, aPTT, D-dimer levels compared to ward patients. PAF-AH activity was significantly increased in ICU patients compared to the control group (p < .05). A positive correlation was found between PAF-AH and D-Dimer in the ICU group.
Conclusion: We found increased PAF-AH activity in patients with Covid-19. It’s important to spot the PAF-AH activity in cardiovascular events that develop due to coagulation problems, which are likely to be seen on these patients in the future.
Subject
General Materials Science
Reference47 articles.
1. D'Amico F, Baumgart D, Danese S, Peyrin-Biroulet L. Diarrhea during COVID-19 infection: Pathogenesis, epidemiology, prevention, and management. Clin Gastroenterol Hepatol. 2020;18(8):1663-1672. DOI: 10.1016/j.cgh.2020.04.001
2. World Health Organization. Critical preparedness, readiness and response actions for COVID-19. Published [22 March 2020]. Updated [27 May 2021]. Accessed [06 March 2022]. https://www.who.int/publications/i/item/critical-preparedness-readiness-and-response-actions-for-covid-19
3. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 2020;395(10229):1054-1062. DOI: 1016/S0140-6736(20)30566-3
4. Tolksdorf K, Buda S, Schuler E, Wieler LH, Haas W. Influenza-associated pneumonia as reference to assess seriousness of coronavirus disease (COVID-19). Euro Surveill. 2020;25(11): 2000258. DOI: 10.2807/1560-7917
5. Siddiqi KH, Mandeep RM. COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal. Journal of Heart and Lung Transplantation 2020; 39(5):405-407. DOI: 10.1016/j.healun.2020.03.012