Cellular Senescence and Matrix Metalloproteinase Activity in Chronic Wounds

Abstract

A prolonged inflammatory response may adversely affect wound closure. Delayed wound closure and extended exposure to chronic wound fluid may also affect cellular activity in a wound bed and result in cellular senescence. Prolonged inflammation and cellular senescence may adversely affect the efficacy of topically-applied biological agents, including growth factors. Appropriate wound bed preparation and debridement are necessary to improve clinical outcomes of new technologies.(J Am Podiatr Med Assoc 92(1): 34-37, 2002)