Reduction in Size and Number of Plantar Verrucae in Human Immunodeficiency Virus–Infected Individuals After the Implementation of Highly Active Antiretroviral Therapy

Author:

Afesllari Endri1,Miller Timothy J.1,Huchital Michael J.1,King Christy M.2,Johnston James S.3,Barbosa Peter1

Affiliation:

1. Division of Preclinical Sciences, New York College of Podiatric Medicine, New York, NY. Dr. Afesllari is now with Henry Ford Macomb Hospital, Clinton Township, Michigan. Dr. Miller is now with Atlantic Health System/Morristown Medical Center, Morristown, NJ.

2. Kaiser Permanente Oakland, Oakland, CA.

3. Orthopedic Surgery Specialists, Aberdeen, SD.

Abstract

Background Implementation of highly active antiretroviral therapy (HAART) significantly increased the life expectancy of those living with human immunodeficiency virus (HIV). Except for prevalence, scientific reports regarding clinical manifestations of plantar verrucae in the post-HAART era are lacking. The objective of this study was to compare clinical manifestations of plantar verrucae between HIV-infected and noninfected individuals and then to compare these findings with those observed before the implementation of HAART. Methods Nineteen patients with plantar verrucae (ten with HIV and nine without HIV) were examined to determine the size, number, and clinical type of verrucae present. The two groups were first compared with each other and then with previously collected data from a similar analysis conducted in 1995, before the implementation of HAART. Statistical significance was determined using the Fisher exact test or the Wilcoxon rank sum test. Results No significant differences were observed in the size, number, or clinical type of verrucae between HIV-negative and HIV-positive patients. Compared with the 1995 data, there was a significant decrease in the number of verrucae lesions per individual and a nonsignificant decrease in the average size of verrucae in HIV-positive patients. Conclusions Study results indicate that the implementation of HAART has impacted the clinical manifestations of plantar verrucae in HIV-positive individuals. Further analyses with a larger number of patients are required to confirm and substantiate these findings.

Publisher

American Podiatric Medical Association

Subject

General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Plantar Verrucae in Human Immunodeficiency Virus Infection;Clinics in Podiatric Medicine and Surgery;2020-04

2. HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management;American Journal of Clinical Dermatology;2019-02-26

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