Comparison of the effect of magnesium sulfate 50 mg/kg with 30 mg/kg on opioid requirement and blood magnesium level after abdominal hysterectomy

Abstract

Background: Hysterectomy is the most common operation with a postoperative pain score for abdominal hysterectomy being 8. Preemptive analgesia can help mitigate the postoperative pain. We studied the effect of preoperative use of magnesium sulfate (MgSO4), either in a dose of 50 mg/kg or 30 mg/kg, on the opioid requirements as well as on the serum magnesium levels in abdominal hysterectomy patients. Methodology: This was a double-blind, randomized controlled, clinical trial with 40 women undergoing abdominal hysterectomy included as participants. The participants were randomly divided into two groups; Group I received MgSO4 30 mg/kg and Group II received a dose of 50 mg/kg, 20 min before induction of routine general anesthesia. Pre-operative and postoperative blood magnesium levels were compared by unpaired t-test. Inter-group comparison was also done. Results: Group I patients had lower postoperative opioid requirements compared to the Group II. There was a significant difference in blood magnesium levels between the two groups; e.g., 2.36 ± 0.29 vs.2.13 ± 0.23 mEq/L in Group I and Group II, respectively. Conclusion: Administering magnesium sulfate at a dose of 50 mg/kg to abdominal hysterectomy patients can reduce the need for opioids and significantly increase the magnesium levels in the blood compared to a dose of 30 mg/kg. Keywords: Abdominal hysterectomy; Magnesium sulfate; Opioid; Preemptive analgesia Citation: Aditya R, Indriasari, Limawan MA. Comparison of the effect of magnesium sulfate 50 mg/kg with 30 mg/kg on opioid requirement and blood magnesium level after abdominal hysterectomy surgery. Anaesth. pain intensive care 2024;28(3):517−523; DOI: 10.35975/apic.v28i3.2469 Received: January 10, 2024; Reviewed: January 10, 2024; Accepted: January 15, 2024