Association of neuregulin-1 with hormonal and lipid profile in women with polycystic ovarian syndrome

Abstract

Background & objective: Polycystic ovarian syndrome (PCOS) is a disorder of the reproductive aged women, which may affect fertility of these women from 14-45 y of age. Neuregulin-1 (NRG-1) is a trophic factor that contains an epidermal growth factor (EGF)-like domain, and has been shown to be associated with the regulation of inflammation and ovulation. We evaluated the role of NRG-1 and its relationship with hormonal and lipid profile in women with PCOS. Methodology: This was a case-control study which included 60 women, known to be suffering from PCOS and another 60 age-matched women, who had regular menstrual cycle, as a control group. Blood samples were collected from Infertility Clinic/ Al-Yarmouk Teaching Hospital. Hormonal and lipid profiles were measured using standard methods. Enzyme linked immunosorbent assay (ELISA) was used to measure serum level of NRG-1. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of NRG-1. Results: The median serum level of neuregulin in patients was 2.73 pg/mL (range = 1.13-7.39 pg/mL) which was higher than that of controls (median = 2.1 pg/mL, range = 0.33-7.39 pg/mL) with a significant difference the area under the curve (AUC) was 0.652, 95%CI = 0.545-0.758, P = 0.008. The sensitivity and specificity of the test at cut off value of NRG-1 = 2.25 were 62% and 52%, respectively. Neuregulin-1 displayed a significant negative correlation with anti-Müllerian hormone (AMH) (r = -0.324, P = 0.038). Conclusions: Serum level of neuregulin-1 is increased in women with polycystic ovarian syndrome, but has a poor diagnostic value, and its negative correlation with anti-Müllerian hormone. However, the diagnostic value of neuregulin-1 is poor and cannot be used in early diagnosis of polycystic ovarian syndrome. Abbreviations: AMH - Anti-Müllerian hormone; AUC - Area under the curve; EGF - Epidermal growth factor; HDL-C - High-density lipoprotein cholesterol; LDL-C - Low-density lipoprotein cholesterol; NRG-1 - Neuregulin-1; PCOS - Polycystic ovarian syndrome; SG - Stress granules; TC - Total cholesterol; TG -Triglyceride. Keywords: Infertility; Neuregulin-1; Polycystic ovarian syndrome Citation: Zaidan OT, Al-Tamimi RJ, Alizzi FJ, Al-Mayah QS. Association of neuregulin-1 with hormonal and lipid profile in women with polycystic ovarian syndrome. Anaesth. pain intensive care 2024;28(3):509−516. DOI: 10.35975/apic.v28i3.2471 Received: March 15, 2024; Revised: March 24, 2024; Accepted: March 29, 2024