Pseudothrombocytopenia — problems and ways to solve diagnostic problems-Reference-Cited by-同舟云学术

Pseudothrombocytopenia — problems and ways to solve diagnostic problems

Published:2023-09-21 Issue:4 Volume:3 Page:38-43
ISSN:2782-3814
Container-title:Russian Journal for Personalized Medicine
language:
Short-container-title:jour

Author:

Zenina M. N.¹,Nuzhdina M. A.²,Chernysh N. Y.³,Yudina V. A.³

Affiliation:

1. North-Western State Medical University named after I. I. Mechnikov; Russian Research Institute of Hematology and Transfusiology of the Federal Medical and Biological Agency of Russia

2. Russian Research Institute of Hematology and Transfusiology of the Federal Medical and Biological Agency of Russia

3. Russian Research Institute of Hematology and Transfusiology of the Federal Medical and Biological Agency of Russia; Almazov National Medical Research Centre

Abstract

EDTA-dependent pseudothrombocytopenia is the laboratory phenomenon of a spurious low platelet count which appears in vitro while using EDTA as anticoagulant. The problem of EDTA-dependent pseudothrombocytopenia has significant relevance due to the widespread using of automated hematology analyzers which EDTA stabilized blood is most recommended for. The mechanism of this phenomenon is based on the production of the specificantibodies causing the platelet aggregation in the presence of EDTA. The aim of this study was to evaluate MgSO4 as an in vitro anticoagulant for platelet count, MPV and correction WBC. Early determination of the patients with EDTA-dependent pseudothrombocytopenia is an important diagnostic criterion necessary to exclude blood diseases and prevent errors in treatment.

Publisher

Arterialnaya Gipertenziya

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