Neсroptosis and the experience of its targeted modulation in the context of personalized medicine

Abstract

   This review gives an overview of the mechanisms of recently described new mode of programmed cell death called necroptosis. We summarize recent studies on the role of necroptosis in the development of various diseases. In addition, the data on pathological changes at the cellular and tissue level induced by targeted deletion of genes encoding key mediators of necroptosis are presented. The limited experience on the use of pharmacological necroptosis modulators for prevention of tissue/organ injury is also described. Furthermore, the perspectives of the clinical use of necroptosis modulators are critically evaluated.