CIRCADIAN BLOOD PRESSURE PROFILE IN YOUNG SUBJECTS WITH PRE-HYPERTENSION

Abstract

and arterial hypertension for the planning of timely and effective prevention. Design and methods.We enrolled 147 people: with optimal and normal BP — 81, with high normal BP — 30 men, and 36 controls. Ambulatory BP monitoring (ABPM) nas performed in the offi ce at the setting of ≪typical working day≫ or 24 +- 1,5 hours with 15 and 30 minute intervals between the measurements during the day and night, respectively.Results.Young people with high normal BP differ from the subjects with normal and optimal BP by a variety of ABPM indices. However, the changes are lower, but similar to those observed in patients with evident hypertension, including increase of mean systolic and diastolic BP, time index of systolic and diastolic BP, and morning BP surge. Young men with high normal BP are also characterized by the family history of the early cardiovascular disease and the presence of cardiocerebral complaints with the frequency similar to that in hypertensive subjects.Conclusions.Young subjects with high normal BP seem to be at higher risk, and should undergo early and effective preventive measures.