Quantitative spect measurement of the tissue blood flow in myocardium by the absolute uptake of radiopharmaceutical <sup>99m </sup>TC -Technetril-Reference-Cited by-同舟云学术

Quantitative spect measurement of the tissue blood flow in myocardium by the absolute uptake of radiopharmaceutical <sup>99m </sup>TC -Technetril

Published:2022-04-15 Issue:1 Volume:9 Page:29-38
ISSN:2410-5155
Container-title:Translational Medicine
language:
Short-container-title:Transl. med. (Print)

Author:

Ussov W. Yu.¹^ORCID,Soukhov V. Yu.²,Babikov V. Yu.³,Borodin O. Yu.⁴,Vorozhtsova I. N.³,Lishmanov Yu. B.⁵,Udut V. V.³,Krivonogov N. G.³

Affiliation:

1. Tomsk Polytechnic University; Tomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute

2. The Nikiforov Russian Center of Emergency and Radiation Medicine, The Ministry of Russian Federation for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters

3. Tomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute

4. Tomsk Polytechnic University; Tomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute; Tomsk Regional Oncology Center

5. Tomsk Polytechnic University

Abstract

Background. Quantitative calculation of tissue blood flow by means of radionuclide emission tomography is of great importance in studies of myocardial blood supply. Quantifying blood flow with PET requires a medical cyclotron. 99mTc-Technetrile is a unique radiopharmaceutical (rfp) with a high and approximately the same extraction fraction by the myocardium and other tissues — chemical microspheres.Objective. Development of a technique for calculating tissue blood flow for a quantitative assessment of the blood supply to the heart muscle, according to the determination of tissue absorption of 99mTc-Technetrile during CardioSPECT.Design and methods. The distribution of rfp — chemical microspheres 99mTc-Technetrile in the body is proportional to blood flow. Determining the amount of accumulation of rfp in different regions can be performed using SPECT. Weused data of 14 patients with myocardial infarction, who underwent SPECT with 99mTc-Technetrile, with the calculation of tissue blood flow.Results. Evaluation of rMBF at rest in the area of unaffected myocardium revealed rMBF = 65±7 ml/min/100 g, in segments with the presence of viable myocardium according to the ultrasound test with dipyridamole rMBF = 53±7 ml/min/100 g, in postinfarction regions of the transmural damage to the left ventricular wall without viable myocardium rMBF = 27±8 ml/min/100 g.Conclusion. The calculation of tissue blood flow via CardioSPECT is useful for pathophysiological assessment of the blood supply to the heart muscle.

Publisher

Arterialnaya Gipertenziya

Reference25 articles.

1. Shlyakhto E V, Baranova E I. Central directions for reducing cardiovascular mortality: what can be changed today ? Russian Journal of Cardiology. 2020; 25(7): 10-18. DOI: 10.15829/1560-4071-2020-3983.

2. Ryzhkova DV, Krasilnikova LA, Nifontov YeM, Tyutin LA, Itskovich IE. Evaluation of coronary bed function by positron emission tomography using 13N-ammonium during cold – stimulation test. Russian Journal of Radiology . 2010; (3): 15-20. (in Russian)

3. Stanzhevskiy AA, Panfilenko AF, Tyutin LA, Ilyushchenko Yu R. Role of positron emission tomography in the hemodynamic evaluation of brain tumors. Russian Journal of Radiology . 2014; (6): 53-61. (in Russian)

4. Ussov W Yu, Garganeeva AA, Fedorov A Yu, Karpov R S. Assessment of myocardial blood flow in absolute units by 99mTc-MIBI SPECT. Technique and clinical trial in coronary patients. Medical Radiology and Radiation safety. 1998; 43(4): 30-36. (in Russian)

5. Wu D, Zhang Z, Ma R, Guo F, Wang L, Fang W. Comparison of CZT SPECT and conventional SPECT for assessment of contractile function, mechanical synchrony and myocardial scar in patients with heart failure. J Nucl Cardiol. 2019; 26(2): 443-452. doi: 10.1007/s12350-017-0952-6.