Influence of the age factor and АСЕ and PAI-1 gene polymorphism on the severity of the new coronavirus infection (SARS-CoV-2).-Reference-Cited by-同舟云学术

Influence of the age factor and АСЕ and PAI-1 gene polymorphism on the severity of the new coronavirus infection (SARS-CoV-2).

Published:2023-12-20 Issue:6 Volume:10 Page:549-556
ISSN:2410-5155
Container-title:Translational Medicine
language:
Short-container-title:Transl. med. (Print)

Author:

Bogdanov D. S.¹,Cherkashin D. V.¹,Ulyatovsky V. A.¹,Shulenin K. S.¹,Efimov S. V.¹,Myakoshina L. A.¹,Butsenko S. A.¹

Affiliation:

1. Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation

Abstract

The paper investigates the role of the association of polymorphic variants of the tissue plasminogen activator inhibitor 1 (PAI-1) and angiotensin-converting enzyme (ACE) genes in 244 patients with coronavirus infection with varying degrees of disease severity (mild, moderate, and the group of deaths). The influence of the age factor in conjunction with various genotypes on the course of coronavirus infection is also being studied. An analysis of the frequencies of alleles and genotypes of ACE found statistically significant differences: the D allele is associated with the severity and outcome of COVID-19. The I/D genotype is associated with a milder course of the disease, while the D/D genotype increases the likelihood of death.

Publisher

Arterialnaya Gipertenziya

Reference12 articles.

1. Shishimorov IN, Magnitskaya OV, Ponomareva YV. Genetic predictors of the severity of the course and the effectiveness of pharmacotherapy of COVID-19. Pharmacy and pharmacology. 2021; 9(3):174–184. In Russian DOI: 10.19163/2307-9266-2021-93-174-184.

2. Sayed-Tabatabaei FA, et al. ACE polymorphisms. Circulation research. 2006;98(9): 1123–1133. DOI: 10.1161/01.RES.0000223145.74217.e7.

3. Timokhina EV, et. al. Polymorphism of the angiotensin-converting enzyme gene ACE significantly increases the risk of developing preeclampsia. Biochemistry. 2019;84(2):281–287. In Russian DOI 10.1134/S0320972519020118. – EDN YVEYAH.

4. Sun F, He N, Zhang K, et al. Association of ACE gene A2350G and I / D polymorphisms with essential hypertension in the northernmost province of China. Clin Exp Hypertens 2018;40(1):32–38. DOI: 10.1080/10641963. 2017.1291659.

5. Gong H, Mu L, Zhang T, et al. Association of polymorphisms of CYP11B2 gene-344C / T and ACE gene I / D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension. Journal of genetics. 2019;(98):1–5. DOI: 10.1007/s12041-018-1053-2.