Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic-Reference-Cited by-同舟云学术

Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic

Published:2012 Issue: Volume:2012 Page:1-5
ISSN:1537-744X
Container-title:The Scientific World Journal
language:en
Short-container-title:The Scientific World Journal

Author:

Chang Hye-Sook¹,Endoh Daiji²^ORCID,Ishida Yushi²,Takahashi Hiroyuki³,Ozawa Shuji⁴,Hayashi Masanobu²,Yabuki Akira¹,Yamato Osamu¹^ORCID

Affiliation:

1. Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan

2. Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Hokkaido 069-8501, Ebetsu, Japan

3. Information Systems Department, Industrial Research Institute, Hokkaido Research Organization, Kita-19 Nishi-11, Hokkaido 060-0819, Sapporo, Japan

4. Laboratory of Natural Products Chemistry, Department of Sustainable Agriculture, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Hokkaido 069-8501, Ebetsu, Japan

Abstract

To evaluate a radioprotective effect of sodiumn-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiving 10 Gy of X-ray irradiation. Cell damage caused by the irradiation was quantified as comet tail moment, which represents the degree of DNA damage. X-ray-induced DNA damage was significantly decreased in both H4IIE and L5178Y cells by micromolar concentrations of NPTS and 2PTS compared with the control without the compounds. The protective effect was more potent with 2PTS than NPTS. Onions and garlic have antiradiation potential.

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Publisher

Hindawi Limited

Subject

General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/tswj/2012/846750.pdf

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