A Randomized Comparative Trial on the Therapeutic Efficacy of TopicalAloe veraandCalendula officinalison Diaper Dermatitis in Children

Abstract

Introduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies ofAloe veracream andCalendula officinalisointment on the frequency and severity of DD in children.Methods. Sixty-six infants with DD (aged < 3 years) were randomized to receive eitherAloecream (n=32) orCalendulaointment (n=34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial.Results. Although improvement in the severity of DD was observed in both treatment groups (P<0.001), patients receivingCalendulaointment had significantly fewer rash sites compared toAloegroup (P=0.001). No adverse effect was reported from either of the medications.Discussion. The evidence from this study suggests that topicalAloeand in particularCalendulacould serve as safe and effective treatment for the treatment of diaper dermatitis in infants.