This study aimed to compare the match running performance between bottom- and top-ranked teams in professional soccer players. In addition, this study verified the independent and interactive effects of playing position and contextual factors on running outputs between these teams. Forty-eight professional male outfield soccer players participated in this study (top-ranked team, n=24; bottom-ranked team, n=24). The distance- and accelerometry-based measures were recorded during 69 matches using a global position system (10 Hz) integrated with an accelerometer (400 Hz). The top-ranked team covered greater total distance and high-acceleration than the bottom-ranked team in home and away matches, mainly for external defenders and midfielders (p < 0.05, effect size [ES]=moderate). The matches against top-level opponents required high values of running outputs only for the top-ranked team (p < 0.05, ES=small). In general, the match outcome (loss vs. draw vs. win) was not influenced by running performance for both bottom- and top-ranked teams (p > 0.05; ES=small), with exception for Player Load (bottom-ranked team: win > draw = loss; p < 0.05, ES=small). These findings should be taken into account when the coaches and practitioners interpret the match running outputs and when evaluating the effects of training intervention on these performance indicators.