Effect of Dietary Prebiotic Safmannan and Bio-antibiotic Fluconazole on some Growth and Haemato-immunological Parameters of Common Carp Cyprinus carpio Linnaeus

Abstract

This study was conducted in the laboratories of the College of Agriculture, University of Basrah for 75 days, in order to study the effect of using prebiotic (Safmannan) and bio-antibiotic (Fluconazole) on some growth and haemato-immunological parameters of the common carp Cyprinus carpio L. The fishes were divided into four categories of treatments; the first treatment was the control (basal diet), the second and third treatments (T2 and T3) contained 500 and 1000 mg.kg-1 diet of Safmannan, respectively while the fourth treatment consisted of adding 150 mg.100 g-1 diet of bio-antibiotic Fluconazole. The second and third treatments were significantly higher (P<0.05) than control and antibiotic treatments in the growth parameters such as the average of daily weight gain, the average of specific growth and the feed conversion of the second and third treatments. Blood proteins (albumin, globulin and total protein) showed significantly higher (p <0.05) values in the second and third treatments than control and antibiotic treatments. No significant differences were noted in both packed cells volume (PCV) and haemoglobin (Hb) among different treatments. The value of alanine aminotransferase (ALT) showed no significant differences among all treatments, while alkaline phosphatase (ALP) was significantly higher and aspartate transaminase (AST) was significantly lower in the fourth treatment. Hepatosomatic index (HSI) was significantly higher in all treatments compared with the control, while no significant differences in spleen somatic index (SSI) were noted among all treatments. Differential white blood count exhibited no significant differences among the treatments for eosinophils, basophils, lymphocytes and monocytes, while neutrophil count was significantly decreased in all treatments in comparison with the control.