Antihyperlipidemic Effect of Ethanol Extract of Lansau a Traditional Medicine of Muna Ethnic, Indonesia

Abstract

Lansau is a traditional herb medicine from Muna ethnic, Southeast Sulawesi, Indonesia, consisting of 44 medicinal plants. This study was performed to determine and evaluate the antihyperlipidemic effect of ethanol extract of Lansau in high cholesterol and propylthiouracil induced hyperlipidemic rats. The animal test Wistar strain were used and divided into six groups namely KN (Na. CMC 1%), K (-) (Na CMC 1% + MDLT), K (+) (simvastatin 0.40 mg/kg BW), LS I (Lansau ethanol extract 6.907 mg/kg BW), LS II (ethanol extract Lansau 13.814 mg/kg BW) and LS III (Lansau LS III ethanol extract 27.628 mg/kg BW. The results showed that ethanol extract of traditional Lansau medicine with dose LS I 6.907 mg/kg BW, LS II 27.628 mg/kg BW and LS III 27.628 mg/kg BW have significant activity as antihyperlipidemic (cholesterol and triglyceride) compared to negative control groups (p <0.05) and showed the same activity with simvastatin in lowering total cholesterol and triglyceride levels (p> 0.05), which shows its potential as antihyperlipidemic herbal medicine.