Intermolecular interactions of apple pectin modified by pharmacophores with iodine and antimicrobial activity of iodine-containing pectin materials

Abstract

New complex compounds based on apple pectin and pharmacologically active organic acids (nicotinic, salicylic, 5-aminosalicylic and anthranilic acids) were synthesized. The obtained complexes were characterized by a number of physicochemical research methods (UV, IR, and 13C NMR spectroscopy, electron microscopy, viscosimetry, polarimetry, and elemental analysis). Based on pharmacophore-containing pectins, stable iodine-containing films were obtained. The effect of the structure of a polysaccharide-modifying drug compound on the properties of iodine-containing polymeric materials was shown: iodine content, time of release of iodine from the film, diffusion and surface characteristics. The formation of a new set of properties in the production of iodine-containing films based on pharmacophore-containing pectins provides an increase in antimicrobial activity by 1.3-1.5 times in comparison with the initial polymer matrices.