Potential of Black Rice (Oryza sativa L.) as Anticancer Through Mortalin-p53 Complex Inhibitors

Abstract

This research was conducted because the number of cancer patients continues to increase so it is very necessary to look for food that has the potential as an anticancer, including black rice (Oryza sativa L.). The research method uses a docking method to identify bioactive compounds in black rice which act as anticancer through the mortalin-p53 complex inhibitor. The analysis showed that the campesterol compound contained in black rice has the potential as a cancer drug that has a mechanism that is by binding to the binding site ligand on mortalin so that it can inhibit the occurrence of the mortalin-p53 complex.