New Candidate Delivery System for Alzheimer’s Disease: Deferoxamine Nanogels

Abstract

This study presents hydrogel nanoparticles made of chitosan and tripolyphosphate via ionotropic gelation technique to evaluate their potential for the association of deferoxamine. Since it has been shown that iron chelation therapy can be useful in the treatment of some neurodegenerative diseases such as Alzheimer's, in this study, we attempted to evaluate the in vitro characteristics of deferoxamine-loaded nanogels for this purpose. Chitosan-based nanogels were prepared and optimized in terms of size by a Taguchi Orthogonal Array design. The spherical structure nanoparticles showed a uniform particle size of 63±2 nm with loading amount, Loading efficiency, and loading ratio of 8.48%±0.021, 26.1%±0.63, and 2.66%±1.88 respectively in optimum conditions. Further study revealed that this nanoparticulate system can be a suitable carrier for the entrapment and control release of small molecules such as deferoxamine.