Design and Two New Indol-Steroid Derivatives to Evaluate their Theoretical Activity Against Protein Kinase 2 (CK2) Protein

Abstract

Several compounds have been developed to evaluate their interaction with CK2-protein surface using some docking models. The objective of this investigation was to prepare two indol-steroid derivatives from 6-nitroprogesterone using some chemical strategies. In addition, the interaction of both compounds 3 and 6 with CK2-protein was evaluated in a docking model using quinalizarin as tool. The results showed that either compounds 3 or 6 have a higher affinity by 3FL9 protein surface compared with quinalizarin. In conclusion, this phenomenon suggests that either compounds 3 or 6 could exert changes in the biological activity of CK2 protein.