2,4-dinitrophenyl hydrazone derivatives as potent of alpha amylase inhibitors

Abstract

Our current attempt was made to synthesize a new 2,4-dinitrophenyl hydrazone derivatives (1–13) compounds and explored their alpha amylase inhibitory potential. The thirteen new derivatives of 2,4-dinitrophenyl hydrazone (1–13) were achieved from the reaction of aliphatic aldehydes and aromatic aldehydes with dinitrophenyl hydrazine in methanol under reflux in the presence of catalyst used acetic acid. The molecular docking study was examined through standard software MOE (Molecular Operating Environment). The result of docking shown that compounds in the catalytic site of enzyme is more potentially active for binding and arrangement. Our results predict compound 12 IC50 =16.42 µg/mL, 5 IC50 =12.16µg/mL, and 6 IC50 =15.03µg/mL more potent and excellent inhibitor than a standard acarbose IC50 = 42.47µg/mL for alpha amylase. It’s concluded that compounds (1–13) can provide us a pathway for new antidiabetic drugs in the market the further analysis and exploration of these compound is important and valuable.