Synthesis and characterization of nontoxic silver nano-particles with preferential bactericidal activity

Abstract

The massive prophylactically or remedially application of antibiotics without proper medical indications lead to severe problems of bacterial resistance. Nanoparticles (NPs) are increasingly applied to target bacterial infections as an antibiotic alternative. Green synthesis of silver nanoparticles (AgNPs), with controlled morphology, within cinnamon extract using microwave irradiation was carried out. The influence of the pH on the synthesized AgNPs was assessed. Physicochemical characterizations were followed through UV, FTIR, FESEM, HRTEM, XPS and XRD analyses. Bactericidal activity and in-vitro cytotoxicity of the achieved AgNPs were investigated. Results proved the successful synthesis of spherical AgNPs with an average size of 15 nm. The AgNPs safety was verified through cytotoxicity test against skin fibroblast normal cells. The obtained AgNPs exhibited promising bactericidal activities against the screening of several Gram+ve and Gram-ve bacteria. Therefore, it can be successfully applied in the biomedical fields for hard and soft tissue remedies.