Ascorbic acid: a naturally green and efficient catalyst for one-pot synthesis of N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates under ambient temperature

Abstract

A naturally green and economical ascorbic acid synthesis of N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates has been accomplished via one-pot four-condensation of dialkylacetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature. The notable advantages of the present procedure are green, natural and low-cost catalyst, operational simplicity, eco-friendly, environmentally benign nature, no necessity of chromatographic purification steps, short reaction times and good to high yields.