Synthesis and screening of novel lipophilic diarylpropeones as prospective antitubercular, antibacterial and antifungal agents

Abstract

Infectious diseases including bacterial, fungal and tuberculosis are responsible for the suffering of humans worldwide. Based on this observation we predetermined to prepare and five novel lipophilic diarylpropenones (Chalcones) (3a-3e) against tubercular, bacterial and fungal strains. The compounds were prepared by base the catalyzed condensation of 2,4,6-trimethyl acetophenone with substituted aromatic aldehydes, purified by recrystallization and characterized by elemental analysis and IR, 1H NMR, and Mass spectroscopic techniques. Further, the compounds were biologically screened for their antitubercular, antibacterial, and antifungal actions. Results of these activities revealed that the compounds possess potential antifungal and antitubercular activities and poor antibacterial activity. The greater activities against tubercular and fungal strains may be due to the lipophilicity rendered by the three magic methyl groups and halogen atoms. The compounds showed no cytotoxicity against the normal human cell line L02. These compounds may act as new scaffolds for the design and development of new molecules against tubercular and fungal infections. Advanced studies need to be carried out in order to determine their potency in vivo.