Abstract
Considering the large number of the multiresistant bacterial strains and the increasing need in new antimicrobial formulation, the aim of this study was to evaluate the antipathogenic effect of E. caryophyllata essential oil on collection and recently isolated clinical strains of P. aeruginosa and S. aureus. Experimental assays were carried out by in vitro and in vivo tests. Qualitative and quantitative assessment of the antimicrobial activity was followed by the analysis of the essential oil influence on enzymatic soluble virulence
factors expression. The cytotoxic effect of the vegetal extract was quantified by using
HeLa cells. Nanosystem embedded essential oil was used to establish the in vivo
antipathogenic effect on mice. Qualitative screening results revealed an early microbicidal
effect quantified by low minimum inhibitory concentration values. The in vivo study
showed a stabiliziation of the essential oil biological activities when using nanosystem
embedding, that could be used for the design of proper formulations for delivery systems
with antimicrobial effect.
Publisher
AMG Transcend Association
Subject
Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology
Cited by
28 articles.
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