Abstract
The great problem associated with drug administration is the inability to target a
specific area of the body. To reach an acceptable therapeutic level, large doses of the
drug must be administered. Only a part of the dose will actually reach the intended
disease. Magnetic targeting simplifies drug administration procedures, increases the
concentration of the drug at target sites and decreases the concentration of the drug at
non-target sites. This study was focused to evaluate the controlled release profile of
cephalosporins from magnetic diethylaminoethyl-cellulose hybrid material (magnetic
scaffold). Dissolution behavior of these magnetic scaffolds was evaluated using a
modified HPLC system. It was found that in all cases, at large time values, the
cephalosporin’s concentration was much below the solubility plateau for the pure active
compound, demonstrating that the adsorption on the surface of magnetic scaffolds is a
valuable procedure to attain controlled release
Publisher
AMG Transcend Association
Subject
Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology
Cited by
13 articles.
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