Recent Developments on the Synthetic and Biological Applications of Chalcones-A Review

Abstract

Chalcones are precursors of the biosynthesis of flavonoids present in plants. These motifs serve a wide range of applications, from synthetic to pharmacological to physical spheres. Chalcone derivatives attracted the scientific community all over the world in recent times due to their diversified applications. The presence of reactive α,β-unsaturated carbonyl moiety in chalcones makes them a versatile intermediate in synthesizing various classes of compounds of biological and physical interest. More importantly, the chalcones themselves have been known to possess enormous biological activities and physical properties like semiconductor, non-linear optical, fluorescence, and electronic properties. In this context, the present review summarises the overall developments in the synthetic, pharmacological, and physical applications of chalcones in recent fast. The critical discussion was attempted on the synthetic applications and biological potencies as anti-cancer, antidiabetic, antimicrobial, antioxidant, and anti-inflammatory.